Type I interferon in rheumatic diseases
نویسندگان
چکیده
منابع مشابه
Type I interferon in systemic autoimmune diseases
Th e hypothesis that type I interferon plays a central role in the pathogenesis of systemic lupus erythematosus (SLE) has gained growing support in recent years [1-4]. Th e early data from the 1970s demonstrating increased functional interferon activity in lupus patient sera have been confi rmed and extended using current technologies that permit detection of the broad gene expression program i...
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Interferons (IFNs) are pivotal regulators of immunological processes. This paper describes mainly type I interferons -α and -β and their recently recounted signaling pathways, especially connected with ISGs - interferon stimulated genes, having a crucial role in regulating IFN recruitment. Moreover, the paper shows the data on the role of interferons -α and -β in infections - not only commonly ...
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ژورنال
عنوان ژورنال: Nature Reviews Rheumatology
سال: 2018
ISSN: 1759-4790,1759-4804
DOI: 10.1038/nrrheum.2018.31